LDN-27219 protein kinase targeting Things To Know Before You Buy
1 particularly appealing compound is LDN-27219. Even though most tTG inhibitors are created to bind towards the protein crosslinking Lively web site, LDN-27219 rather binds to your nucleotide binding pocket in the enzyme whilst it is actually in its closed-condition conformation, and stabilizes that conformation to stop crosslinking activity.sevent